SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity, selective TRPV6 calcium channel inhibitor with IC50 of 14 nM. SOR-C13 binds to TRPV6 in ovarian cancer cells with high affinity. SOR-C13 inhibit calcium influx in TRPV6 over-expressing cells and is more effective at reducing cell viability than cis-Platin. SOR-C13 (400, 600 and 800 mg/kg, daily i.p.) over 12 days significantly reduces ovarian tumour growth in NOD/SCID mice bearing xenografted ovarian tumours.
