SOS1 activator 17 |CAS:2228955-02-8 Probechem Biochemicals

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Ras-SOS1 activator 17

Chemical Structure : SOS1 activator 17

SOS1 activator 17

Catalog No.: PC-35391Not For Human Use, Lab Use Only.

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro.
SOS1 activator 17 activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels.

Physicochemical Properties

M.Wt	496.436
Formula	C26H27Cl2N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-Amino-3-(6-chloro-1H-indol-3-yl)-1-(5-((5-chloro-1H-indol-3-yl)methyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propan-1-one

References

1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com