Chemical Structure : SOS1 inhibitor SL43
CAS No.:
SOS1 inhibitor SL43
Catalog No.: PC-26521Not For Human Use, Lab Use Only.
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM).
SL43 exhibited potent and selective antiproliferative activity against KRAS-mutant colorectal cancer cells (IC50 = 0.028–0.238 μM), achieving over 100-fold selectivity over KRAS wild-type cells.
SL43 (20 and 40 mg/kg, p.o.) also significantly suppressed tumor growth (TGI = 57.2% and 74.9%, respectively), outperforming MRTX0902 (60 mg/kg, TGI = 47.1%) with no observable systemic toxicity.
Physicochemical Properties
|
M.Wt
|
449.04
|
|
Formula
|
C27H33ClN4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(R)-N4-(1-(4-chlorophenyl)ethyl)-6-(cyclohex-1-en-1-yl)-N2-neopentylquinazoline-2,4-diamine
|
References
1. Liu X, et al. Bioorg Chem. 2026 Apr 2;175:109823.
Contact Us
sales@probechem.com
