Catalog No.: PC-38828Not For Human Use, Lab Use Only.
SOX18 inhibitor Sm4 is a specific, orally active transcription factor SOX18 inhibitor, inhibits SOX18-DNA binding and SOX18-dependent transactivation, directly disrupts SOX18 interaction with a subset of binding partners.
SOX18 inhibitor Sm4 is a specific, orally active transcription factor SOX18 inhibitor, inhibits SOX18-DNA binding and SOX18-dependent transactivation, directly disrupts SOX18 interaction with a subset of binding partners.
Sm4 disrupts the DNA-binding activity of a wide range of HMG boxes from various SOX proteins when used at high concentration (200-300 uM).
Sm4 disrupts SOX18-RBPJ interaction with IC50 of 42.3 uM, has has no effect on SOX18-MEF2C interaction.
Sm4 (25 mg/kg) suppresses vessel formation in a murine model of infantile hemangioma (IH).
