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SP-8008

Chemical Structure : SP-8008

CAS No.: 2088247-61-2

SP-8008 (PCA-8008)

Catalog No.: PC-47038Not For Human Use, Lab Use Only.

SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.
SP‐8008 binds to von Willebrand factor (vWF) at the protein-protein interaction site and inhibits the binding of GP Ib through electrostatic and steric repulsion.
SP‐8008 selectively inhibited platelet aggregation under high shear stress conditions.
SP‐8008 (5-25 mg/kg, oral) exhibited highly potent antiplatelet and antithrombotic effects by selectively attenuating platelet activation and aggregation, induced by shear stress in vivo.

Physicochemical Properties

M.Wt 288.299
Formula C16H16O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-ethyl-3-(2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl)-4H-pyran-4-one

References

1. Thien Ngo, et al. Br J Pharmacol. 2020 Feb;177(4):929-944.

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