Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-SP-8008
SP-8008

Chemical Structure : SP-8008

CAS No.: 2088247-61-2

SP-8008 (PCA-8008)

Catalog No.: PC-47038Not For Human Use, Lab Use Only.

SP-8008 (PCA-8008) is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SP-8008 (PCA-8008) is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.
    SP‐8008 binds to von Willebrand factor (vWF) at the protein-protein interaction site and inhibits the binding of GP Ib through electrostatic and steric repulsion.
    SP‐8008 selectively inhibited platelet aggregation under high shear stress conditions.
    SP‐8008 (5-25 mg/kg, oral) exhibited highly potent antiplatelet and antithrombotic effects by selectively attenuating platelet activation and aggregation, induced by shear stress in vivo.

    Physicochemical Properties

    M.Wt 288.299
    Formula C16H16O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-ethyl-3-(2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl)-4H-pyran-4-one

    References

    1. Thien Ngo, et al. Br J Pharmacol. 2020 Feb;177(4):929-944.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: