Chemical Structure : SPH7050
CAS No.:
2764795-93-7
SPH7050
(SPH-7050)
Catalog No.: PC-27867Not For Human Use, Lab Use Only.
SPH7050 is a gut-restricted Lanthionine synthetase C-like protein 2 (LANCL2) agonist, binds LANCL2 with SPR KD of 2.73 uM, inhibits prostaglandin E2 (PGE2) production in bone marrow-derived macrophages (BMDMs) with IC50 of 0.85 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SPH7050 is a gut-restricted Lanthionine synthetase C-like protein 2 (LANCL2) agonist, binds LANCL2 with SPR KD of 2.73 uM, inhibits prostaglandin E2 (PGE2) production in bone marrow-derived macrophages (BMDMs) with IC50 of 0.85 uM.
SPH7050 binds more deeply than Omilancor (BT-11), making a hydrogen bond to GLU-213 and cation–π interactions with LYS-164 and ARG-118.
SPH7050 (50 mg/kg, p.o.) significantly alleviated TNBS-induced colitis in vivo.
SPH7050 has intestinal-restricted absorption with minimal systemic exposure.
Physicochemical Properties
|
M.Wt
|
540.59
|
|
Formula
|
C31H24N8O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-((1R,5S,6s)-3-(6-(1H-benzo[d]imidazole-2-yl)picolinoyl)-3-azabicyclo[3.1.0]hexan-6-yl)-6-(1H-benzo[d]imidazole-2-yl)picolinamide
|
References
1. Zhao M, et al. Eur J Med Chem. 2026 Aug 13;319:119236.
Contact Us
sales@probechem.com
