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Chemical Structure : SPHINX31
CAS No.: 1818389-84-2
Catalog No.: PC-35908Not For Human Use, Lab Use Only.
SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM, displays no significant activity against other splicing modulating kinases (CLK family, DYRK1A and DYRK2, DYRK5, SRPK-2/3, PIM1, PIM2 kinases).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM.
SPHINX31 displays no significant activity against other splicing modulating kinases (CLK family, DYRK1A and DYRK2, DYRK5, SRPK-2/3, PIM1, PIM2 kinases).
SPHINX31 inhibits SRPK1 mediated SRSF1 phosphorylation in PC3 prostate cancer cells with EC50 of 360 nM, dose-dependently switches splicing from VEGF-A165a to VEGF-A165b in RPE cells.
SPHINX31 potently inhibits blood vessel growth in models of choroidal angiogenesis in vivo.
| M.Wt | 507.517 | |
| Formula | C27H24F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-pyridin-4-yl-N-[2-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-5-(trifluoromethyl)phenyl]furan-2-carboxamide |
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1. Batson J, et al. ACS Chem Biol. 2017 Mar 17;12(3):825-832.
2. Tzelepis K, et al. Nat Commun. 2018 Dec 19;9(1):5378.
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