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SPI-0324

Chemical Structure : SPI-0324

CAS No.: 753466-41-0

SPI-0324 (SPI-24)

Catalog No.: PC-21804Not For Human Use, Lab Use Only.

SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt.
SPI-0324 lowers mutant Htt protein levels in huntington's disease (HD) cells.
SPI-0324 selectively inhibits the expression of the mutant Htt gene without affecting the expression of the normal gene or other Spt5 activities.
SPI-0324 5 mM (5 µg/day) selectively reduces mutant Htt in mutant BACHD mice.
SPI-0324 attenuates HD-related behavioral phenotypes in BACHD mice, shows significant improvements in motor coordination, anxiety symptoms, and when administered to early-stage BACHD mice, slows down the progressive deterioration of the disease.
Short or prolonged SPI-24 treatments does not cause changes in global gene expression or notable side effects.

Physicochemical Properties

M.Wt 390.90
Formula C18H15ClN2O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Chloro-2-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]benzoxazole

References

1. Bahat A, et al. EMBO Mol Med. 2024 Feb 19. doi: 10.1038/s44321-023-00020-y.

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