Chemical Structure : SPI-0324
CAS No.:
753466-41-0
SPI-0324
(SPI-24)
Catalog No.: PC-21804Not For Human Use, Lab Use Only.
SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt.
SPI-0324 lowers mutant Htt protein levels in huntington's disease (HD) cells.
SPI-0324 selectively inhibits the expression of the mutant Htt gene without affecting the expression of the normal gene or other Spt5 activities.
SPI-0324 5 mM (5 µg/day) selectively reduces mutant Htt in mutant BACHD mice.
SPI-0324 attenuates HD-related behavioral phenotypes in BACHD mice, shows significant improvements in motor coordination, anxiety symptoms, and when administered to early-stage BACHD mice, slows down the progressive deterioration of the disease.
Short or prolonged SPI-24 treatments does not cause changes in global gene expression or notable side effects.
Physicochemical Properties
|
M.Wt
|
390.90
|
|
Formula
|
C18H15ClN2O2S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-Chloro-2-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]benzoxazole
|
References
1. Bahat A, et al. EMBO Mol Med. 2024 Feb 19. doi: 10.1038/s44321-023-00020-y.
Contact Us
sales@probechem.com
