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SPI-21

Chemical Structure : SPI-21

CAS No.: 204703-71-9

SPI-21 (Spt5-Pol II inhibitor 21)

Catalog No.: PC-73083Not For Human Use, Lab Use Only.

SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.

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Biological Activity

SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.
Short-term SPI-21 treatment to HeLa cells caused a transcription upregulation (≥2-fold) of 1,371 genes, among them A20 (TNFAIP3), IL-6, IL-8 (CXCL8), and CCL20 (analyzed above), while CXCL2, IEX1 (IER3), and JUNB were unchanged.
SPI-21 precisely mimics the effect of Spt5 depletion on basal and activated NF-κB target genes and on the expanded repeat Htt gene.
Spt5 is a conserved and essential transcription elongation factor that promotes promoter-proximal pausing, promoter escape, elongation, and mRNA processing.
SPI-21 is a useful chemical probe to elucidate the function of Spt5.

Physicochemical Properties

M.Wt 270.284
Formula C16H14O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-1-(2,5-dihydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

References

1. Bahat A, et al. Mol Cell. 2019 Nov 21;76(4):617-631.e4.

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