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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-SR-16234
SR-16234

Chemical Structure : SR-16234

CAS No.: 229634-97-3

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SR-16234 (TAS-108, SR16234)

Catalog No.: PC-23322Not For Human Use, Lab Use Only.

SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions.
SR-16234 (TAS-108) inhibits co-activator recruitment and induce co-repressor recruitment to ERα without preventing ERα-DNA binding.
SR-16234 (TAS-108) acts as pure antagonists for the ERα (D351Y) mutant derived from a tamoxifen-resistant breast cancer cell line.

Physicochemical Properties

M.Wt 505.74
Formula C33H47NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7S,13R,17R)-17-(2-(4-((diethylamino)methyl)-2-methoxyphenoxy)ethyl)-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

References

1. Harada T, et al. Yonago Acta Med. 2018 Feb 5;60(4):227-233.

2. Yamamoto Y, et al. Clin Cancer Res. 2005 Jan 1;11(1):315-22.

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