SR10221 | PPARγ inverse agonist | Probechem Biochemicals

Chemical Structure : SR10221

CAS No.: 1415321-64-0

SR10221 (SR 10221)

Catalog No.: PC-49401Not For Human Use, Lab Use Only.

SR10221 is a potent, selective PPARγ inverse agonist with IC50 of 13 nM in biochemical peptide recruitment assays, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

SR10221 is a potent, selective PPARγ inverse agonist with IC50 of 13 nM in biochemical peptide recruitment assays, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

Physicochemical Properties

M.Wt	561.119
Formula	C33H37ClN2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(5-((5-(((S)-1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-2-chlorophenoxy)propanoic acid

References

1. Sean Irwin, et al. J Biol Chem. 2022 Sep 28;298(11):102539.

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SR10221 (SR 10221)

Biological Activity

Physicochemical Properties

References

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