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Chemical Structure : SR12418
CAS No.: 1801185-08-9
Catalog No.: PC-22073Not For Human Use, Lab Use Only.
SR12418 (SR-12418) is a potent, selective REV-ERB ligand/agonist with IC50 of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively, in TR-FRET biochemical assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | $798 | In stock | |
| 100 mg | Get quote |
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SR12418 (SR-12418) is a potent, selective REV-ERB ligand/agonist with IC50 of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively, in TR-FRET biochemical assay.
SR12418 is more potent than SR9009.
SR12418 also shows minimal off-target activity in a CEREP (Eurofins Scientific) panel screen of 84 G-protein coupled receptors, ion channels, and transporters.
SR12418 dose-dependently inhibits Il17a lucif-erase activity at REV-ERBα and REV-ERBβ and inhibitsTH17 cell differentiation without affecting viability or other T helper populations.
SR12418 potently represses TH17-mediated gene expression and Nfil3, which is consistent with REV-ERBα acting as a repressor at RORE and/or RevRE sites.
SR12418 (i.p., 50mg/kg, b.i.d.) potently suppresses the development and severity of MOG-induced EAE model, inhibits TH17-mediated autoimmunity.
| M.Wt | 483.58 | |
| Formula | C31H30FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(3S)-3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-6-fluoro-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone |
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1. Amir M, et al. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8.
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