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Chemical Structure : SR142948
Catalog No.: PC-60948Not For Human Use, Lab Use Only.
SR142948 is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM.
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SR142948 is a potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM.
SR142948 antagonizes neurotensin-induced inositol monophosphate formation in HT 29 cells with IC50 of 3.9 nM.
SR142948 inhibits the turning behavior induced by neurotensin in mice, completely antagonizes neurotensin-evoked acetylcholine release in the rat striatum at 0.1 mg/kg.
SR142948 also blocks both hypothermia and analgesia induced by i.c.v. injection of neurotensin injection into the ventral tegmental area.
| M.Wt | 685.87 | |
| Formula | C39H51N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gully D, et al. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12.
2. Betancur C, et al. Eur J Pharmacol. 1998 Feb 5;343(1):67-77.
3. Schaeffer P, et al. J Cardiovasc Pharmacol. 1998 Apr;31(4):545-50.
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