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Chemical Structure : SR1664
CAS No.: 1338259-05-4
Catalog No.: PC-60333Not For Human Use, Lab Use Only.
SR1664 (SR-1664) is a potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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SR1664 (SR-1664) is a potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.
SR1664 exhibits potent anti-diabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PPARγ drugs.
SR1664 effectively improves glucose homeostasis, and does not affect bone cell mineralization in culture.
| M.Wt | 547.6 | |
| Formula | C33H29N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid |
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1. Choi JH, et al. Nature. 2011 Sep 4;477(7365):477-81.
2. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.
3. Marciano DP, et al. Nat Commun. 2015 Jun 12;6:7443.
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