Catalog No.: PC-26879Not For Human Use, Lab Use Only.
SR3335 (ML176) is a potent, selective RORα inverse agonist with binding Ki of 220 nM, significantly inhibits the constitutive transactivation activity of RORα with IC50 of 480 nM.
SR3335 (ML176) is a potent, selective RORα inverse agonist with binding Ki of 220 nM, significantly inhibits the constitutive transactivation activity of RORα with IC50 of 480 nM. SR3335 also displays no activity on RORβ (radioligand binding or cotransfection assays), FXR (cotransfection assays) or any other receptors in a selectivity panel for human nuclear receptors. SR3335 (5 uM) suppresses expression of both G6Pase and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in HepG2 cells. SR3335 (15 mg/kg b.i.d., i.p.) suppresses gluconeogenesis in diet induced obese mice.
