Catalog No.: PC-35194Not For Human Use, Lab Use Only.
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM (LIMK1), displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).
SR7826 inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases.
SR7826 potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.
