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SR9009

Chemical Structure : SR9009

CAS No.: 1379686-30-2

SR9009 (Stenabolic, SR 9009)

Catalog No.: PC-47043Not For Human Use, Lab Use Only.

Stenabolic (SR9009) is a potent, synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.

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Biological Activity

Stenabolic (SR9009) is a potent, synthetic REV-ERB agonist with IC50s of 670 nM and 800 nM for REV-ERB-α and for REV-ERB-β, respectively.
SR9009 decreases circadian locomotor activity during the dark phase and to alter the expression pattern of core clock genes in the hypothalami of mice.
SR9009 (i.p. two times a day for 30 days) displays decreased fat mass and markedly improved dyslipidemia and hyperglycemia.

Physicochemical Properties

M.Wt 437.9
Formula C20H24ClN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester

References

1. Laura A Solt, et al. Nature. 2012 Mar 29;485(7396):62-8.

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