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SRI-29329

Chemical Structure : SRI-29329

CAS No.: 2086809-58-5

SRI-29329 (SRI29329;SRI 29329)

Catalog No.: PC-61027Not For Human Use, Lab Use Only.

SRI-29329 (SRI29329) is a potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and 4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRI-29329 (SRI29329) is a potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and 4, respectively.
SRI-29329 shows no significant activity for CLK3, CDK1, CDK4 and CDK6 (IC50>1,000 nM).

Physicochemical Properties

M.Wt 399.927
Formula C20H26ClN7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N2-((1S,2S)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-isopropyl-9H-purine-2,6-diamine

References

1. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.

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