SRJ-23 |CAS:865285-29-6 Probechem Biochemicals

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Chemical Structure : SRJ-23

SRJ-23 (SRJ23;SRJ 23)

Catalog No.: PC-70353Not For Human Use, Lab Use Only.

A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation; significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive; reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells; induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.

Physicochemical Properties

M.Wt	317.704
Formula	C15H9ClFN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide

References

1. Hocker HJ, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10201-6.

2. Jada SR, et al. Br J Pharmacol. 2008 Nov;155(5):641-54.

3. Wong HC, et al. Cell Biol Toxicol. 2014 Oct;30(5):269-88.

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SRJ-23 (SRJ23;SRJ 23)

Biological Activity

Physicochemical Properties

References

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