SRJ23 is a semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.
SRJ23 significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive.
SRJ23 reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells.
SRJ23 induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.
