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Chemical Structure : SRPIN340
CAS No.: 218156-96-8
Catalog No.: PC-49772Not For Human Use, Lab Use Only.
SRPIN340 (SRPIN 340) is a potent, highly selective inhibitor of serine-arginine-rich protein kinase (SRPK1) with Ki value of 0.89 uM (SRPK1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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SRPIN340 (SRPIN 340) is a potent, highly selective inhibitor of serine-arginine-rich protein kinase (SRPK1) with Ki value of 0.89 uM (SRPK1).
SRPIN340 does not significantly inhibit other SRPK, such as Clk1 and Clk4, as well as any additional Ser/Thr kinases.
SRPIN340 is highly specific for both kinases SRPK1 and SRPK2.
SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner.
SRPIN340 (40 μM) rescues Vero cells from the cytopathic effect of Sindbis virus, with IC50 of 60 uM for Sindbis virus propagation.
SRPIN340 suppressed in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro.
SRPIN340 also shows significant cytotoxic activity on lymphoid and myeloid leukemia cell lines, triggers early and late events of apoptosis.
| M.Wt | 349.36 | |
| Formula | C18H18F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide |
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1. Fukuhara T, et al. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33.
2. Siqueira RP, et al. PLoS One. 2015 Aug 5;10(8):e0134882.
3. Karakama Y, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3179-86.
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