Chemical Structure : SRPK1 inhibitor DBS1
CAS No.:
SRPK1 inhibitor DBS1
(Docking Blocker of SRPK1)
Catalog No.: PC-49774Not For Human Use, Lab Use Only.
SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1) is a 20-mer peptide, cell-penetrating, non-ATP-competitive inhibitor of SRPK1 with ITC Kd of 5.6 uM, inhibits kinase activity of SRPK1 in a competitive manner against the substrate SRSF1 (Ki=2.12 uM), but not ATP.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SRPK1 inhibitor DBS1 (Docking Blocker of SRPK1) is a 20-mer peptide, cell-penetrating, non-ATP-competitive inhibitor of SRPK1 with ITC Kd of 5.6 uM, inhibits kinase activity of SRPK1 in a competitive manner against the substrate SRSF1 (Ki=2.12 uM), but not ATP.
DBS1 inhibited both SRPKs but not CLK1 or Akt/PKB, confirming it specifically targets the SRPK docking groove.
DBS1 inhibited SR protein phosphorylation in treated cells, switches the VEGF pre-mRNA splicing from VEGF165 to VEGF165b dose-dependently.
DBS1 is noncytotoxic to HUVECs and could potently inhibit angiogenesis.
Cotreatment of DBS1 with ATP-competitive inhibitor of SRPK1 (SRPIN340) inhibits angiogenesis more effectively.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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