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Chemical Structure : SRPKIN-1
CAS No.: 2089226-94-6
Catalog No.: PC-63234Not For Human Use, Lab Use Only.
SRPKIN-1 (JH-XI-05-01) is a potent, selective, covalent SRPK1/2 inhibitor with IC50 of 35.6/98 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $468 | In stock | |
| 25 mg | $788 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SRPKIN-1 (JH-XI-05-01) is a potent, selective, covalent SRPK1/2 inhibitor with IC50 of 35.6/98 nM, respectively.
SRPKIN-1 significantly attenuates SR protein phosphorylation in HeLa cells at 200 nM, switches VEGF splicing to produce the VEGF-A165b isoform (at 100 nM), converts the pro-angiogenic VEGF-A165a to the anti-angiogenic VEGF-A165b isoform, therefore functioning as an antagonist for VEGF-A165a to block angiogenesis.
SRPKIN-1 blocks laser-induced neovascularization in a murine retinal model.
| M.Wt | 472.534 | |
| Formula | C27H21FN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)benzenesulfonyl fluoride |
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1. Hatcher JM, et al. Cell Chem Biol. 2018 Feb 14. pii: S2451-9456(18)30035-7.
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