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SRX3207

Chemical Structure : SRX3207

CAS No.: 2254693-15-5

SRX3207 (SRX-3207)

Catalog No.: PC-38196Not For Human Use, Lab Use Only.

SRX3207 (SRX-3207) is a potent, orally active dual Syk/PI3K inhibitor with IC50 of 39.9/244/388 nM for Syk/PI3Kα/PI3Kδ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRX3207 (SRX-3207) is a potent, orally active dual Syk/PI3K inhibitor with IC50 of 39.9/244/388 nM for Syk/PI3Kα/PI3Kδ, respectively.
SRX3207 potently blocks immunosuppressive gene expression effectively at very low dose compared to commercially available p110γ inhibitor (IPI-549) or Syk inhibitor (R488) alone, didn't affect T cell proliferation.

Physicochemical Properties

M.Wt 555.657
Formula C29H29N7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[4-[[4-[4-(1-Azetidinylmethyl)-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]phenyl]-5-(4-morpholinyl)-7H-thieno[3,2-b]pyran-7-one

References

1. Shweta Joshi, et al. Mol Cancer Ther. 2020 Mar;19(3):755-764.

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