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SRX3212

Chemical Structure : SRX3212

CAS No.: 2735720-80-4

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SRX3212 (SRX 3212)

Catalog No.: PC-73382Not For Human Use, Lab Use Only.

SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα.
    SRX3212 demonstrated strong anti-cancer activity in cyclinD1 dependent mantle cell lymphoma cell lines (Jeko-1, Mino and Z138), a colon carcinoma cell line (HCT116), a MYCN amplified p53 mutated neuroblastoma cell line (SKNBE2) and a PTEN mutated prostate cancer cell line (PC3), with nanomolar to low micromolar IC50 values.

    Physicochemical Properties

    M.Wt 505.545
    Formula C26H23N3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(5-Morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide

    References

    1. Kendra R Vann, et al. Sci Rep. 2020 Jul 21;10(1):12027.

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