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SSR411298

Chemical Structure : SSR411298

CAS No.: 666860-59-9

SSR411298 (SSR-411298)

Catalog No.: PC-62533Not For Human Use, Lab Use Only.

SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).

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    Biological Activity

    SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).
    SSR411298 potently increases hippocampal levels of AEA, OEA and PEA in mice.
    SSR411298 produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress models.

    Physicochemical Properties

    M.Wt 402.447
    Formula C21H26N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-amino-2-oxoethyl (3-((2r,5r)-5-(6-methoxynaphthalen-1-yl)-1,3-dioxan-2-yl)propyl)carbamate

    References

    1. Griebel G, et al. Sci Rep. 2018 Feb 5;8(1):2416.

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