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SSR 411298

Chemical Structure : SSR 411298

CAS No.: 666860-59-9

SSR 411298 (SSR411298)

Catalog No.: PC-62533Not For Human Use, Lab Use Only.

SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH); potently increases hippocampal levels of AEA, OEA and PEA in mice, produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress models.

Anxiety

Phase 1 Clinical

Physicochemical Properties

M.Wt 402.447
Formula C21H26N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-amino-2-oxoethyl (3-((2r,5r)-5-(6-methoxynaphthalen-1-yl)-1,3-dioxan-2-yl)propyl)carbamate

References

1. Griebel G, et al. Sci Rep. 2018 Feb 5;8(1):2416.

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