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ST034307

Chemical Structure : ST034307

CAS No.: 133406-29-8

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ST034307 (ST 034307, ST-034307)

Catalog No.: PC-70041Not For Human Use, Lab Use Only.

ST034307 (ST 034307, ST-034307) is a potent, selective adenylyl cyclase 1 (AC1) with IC50 of 2.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ST034307 (ST 034307, ST-034307) is a potent, selective adenylyl cyclase 1 (AC1) with IC50 of 2.3 uM.
ST034307 shows no activity against other AC isoforms.
ST034307 inhibits Ca2+-stimulated cAMP accumulation in HEK cells, also inhibits AC1 activity stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells.
ST034307 reduces pain responses in a mouse model of inflammatory pain.

Physicochemical Properties

M.Wt 297.95
Formula C10H4Cl4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-chloro-2-(trichloromethyl)-4H-chromen-4-one

References

1. Brust TF, et al. Sci Signal. 2017 Feb 21;10(467). pii: eaah5381.

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