STK10 inhibitor 23

Chemical Structure : STK10 inhibitor 23

Catalog No.: PC-25740Not For Human Use, Lab Use Only.

STK10 inhibitor 23 is a potent, selective inhibitor of STK10 (serine/threonine kinase 10, LOK) with IC50 of 0.85 uM.

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Biological Activity

STK10 inhibitor 23 is a potent, selective inhibitor of STK10 (serine/threonine kinase 10, LOK) with IC50 of 0.85 uM.
STK10 inhibitor 23 has EC50 of 0.89 uM in NanoBRET assays and SPR Kd of 365 nM.
STK10 inhibitor 23 shows excellent selectivity toward approximately 90 kinases as well as toward closely related kinases within the STE20 subfamily such as STK3/4 and especially toward the closest relative SLK.

Physicochemical Properties

M.Wt	492.96
Formula	C25H25ClN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=C2C=C1OCCOCCNC3=NC4=C2C=NN4C=C3)NCC5=CC=C(C=C5C)Cl

References

1. Dettenhöfer M, et al. ACS Med Chem Lett. 2025 Oct 14;16(11):2086-2096.

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