Chemical Structure : STL001
CAS No.:
STL001
(STL-001)
Catalog No.: PC-22337Not For Human Use, Lab Use Only.
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.
STL001 (1, 5, and 10 μM) resulting in a dose-dependent reduction of the cellular levels of FOXM1 protein in human solid tumor-derived cell lines with high FOXM1 expression levels, including ovarian cancer (OVCAR-8, ES-2), colorectal cancer (HCT-116, HCT-FET), esophageal cancer (FLO-1), hormone receptor-positive (TAM-R) and triple negative (HCC-1143) breast cancers, and prostate cancer (22Rv1, LNCaP).
STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation.
STL001-induced FOXM1 suppression sensitizes human cancers of different origin to a broad-spectrum of cancer therapies.
Physicochemical Properties
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M.Wt
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509.53
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Formula
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C27H23N7O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(1-(4-morpholino-6-(phenylamino)-1,3,5-triazin-2-yl)-1H-pyrazol-3-yl)phenyl furan-2-carboxylate
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References
1. Raghuwanshi S, et al. Cell Death Discov. 2024 May 2;10(1):211.
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