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Chemical Structure : STL001
Catalog No.: PC-22337Not For Human Use, Lab Use Only.
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.
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STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines.
STL001 (1, 5, and 10 μM) resulting in a dose-dependent reduction of the cellular levels of FOXM1 protein in human solid tumor-derived cell lines with high FOXM1 expression levels, including ovarian cancer (OVCAR-8, ES-2), colorectal cancer (HCT-116, HCT-FET), esophageal cancer (FLO-1), hormone receptor-positive (TAM-R) and triple negative (HCC-1143) breast cancers, and prostate cancer (22Rv1, LNCaP).
STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation.
STL001-induced FOXM1 suppression sensitizes human cancers of different origin to a broad-spectrum of cancer therapies.
| M.Wt | 509.53 | |
| Formula | C27H23N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Raghuwanshi S, et al. Cell Death Discov. 2024 May 2;10(1):211.
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