STL1267 | REV-ERB agonist | Probechem Biochemicals

Chemical Structure : STL1267

CAS No.: 1429024-58-7

STL1267 (STL 1267)

Catalog No.: PC-20752Not For Human Use, Lab Use Only.

STL1267 is a specific, high affinity synthetic agonist of nuclear receptor REV-ERB with EC50 of 0.13 uM and Ki of 0.16 uM, binds directly to the ligand binding domain (LBD) of REV-ERB.

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5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$328	In stock
50 mg	$528	In stock
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Biological Activity

STL1267 is a specific, high affinity synthetic agonist of nuclear receptor REV-ERB with EC50 of 0.13 uM and Ki of 0.16 uM, binds directly to the ligand binding domain (LBD) of REV-ERB.
STL1267 is more than ten times greater than SR9009 (EC50 = 1.9 μM).
STL1267 binds to REV-ERB, resulting the recruitment of NCoR and regulation of downstream target genes.
STL1267 displays no activity against a range of NRs including AR, GR, MR, PR, ERα, ERβ, TRα, LXRα, RARα, RXRα, FXR, and VDR.
STL1267 can successfully crosses the blood brain barrier, STL1267 is a valuable tool compound for studying REV-ERB function both in vitro and in vivo.

Physicochemical Properties

M.Wt	322.75
Formula	C17H11ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-([1,1'-Biphenyl]-2-yloxy)-3-chloro-1,2,4-triazolo[4,3-b]pyridazine

References

1. Meghan H Murray, et al. Nat Commun. 2022 Nov 21;13(1):7131.

STL1267 (STL 1267)

Biological Activity

Physicochemical Properties

References

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