Catalog No.: PC-60419Not For Human Use, Lab Use Only.
STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
STL127705 impairs DNA-PKCS autophospho-rylation at the Ser2056 residue, inhibits the Ku-dependent activation of the DNA-PKCS kinase in human cells.
STL127705 synergistically sensitizes human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair.
