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Chemical Structure : STL127705
CAS No.: 1326852-06-5
Catalog No.: PC-60419Not For Human Use, Lab Use Only.
STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
STL127705 impairs DNA-PKCS autophospho-rylation at the Ser2056 residue, inhibits the Ku-dependent activation of the DNA-PKCS kinase in human cells.
STL127705 synergistically sensitizes human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair.
| M.Wt | 437.431 | |
| Formula | C22H20FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
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1. Weterings E, et al. DNA Repair (Amst). 2016 Jul;43:98-106.
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