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Chemical Structure : STOCK1S-14279
Catalog No.: PC-72594Not For Human Use, Lab Use Only.
STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1.
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STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM.
STOCK1S-14279 inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1.
STOCK1S-14279 demonstrated a dose-dependent inhibitory effect of phosphorylation of endogenous NCC (pThr53) in mpkDCT cells and of NKCC1 (pThr206) in MOVAS cells.
STOCK1S-14279 rapidly and markedly reduced NCC phosphorylation (pSer71) with total NCC reduction was observed in the kidneys after 30 minutes of drug administration (in the aorta of mice intraperitoneally injected with 20 mg/kg).
| M.Wt | 537.615 | |
| Formula | C23H13BrCl3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kikuchi E, et al. J Am Soc Nephrol. 2015 Jul; 26(7):1525-36.
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