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STS66

Chemical Structure : STS66

CAS No.: 2377670-64-7

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STS66 (NKCC1 inhibitor STS66)

Catalog No.: PC-72596Not For Human Use, Lab Use Only.

STS66 is a novel BBB-penetrant Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, reduces brain damage in mice after ischemic stroke.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STS66 is a novel BBB-penetrant Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, reduces brain damage in mice after ischemic stroke.
    STS66 treatment completely blocked the ischemia-induced elevation of pNKCC1, which is superior to BMT and STS5.
    STS66 showed efficacy against permanent focal ischemic brain injury with hypertension comorbidity.

    Physicochemical Properties

    M.Wt 431.474
    Formula C19H24F3N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(Butylamino)-2-phenoxy-5-[(2,2,2-trifluoroethylamino)methyl]benzenesulfonamide

    References

    1. Huachen Huang, et al. Stroke. 2019 Apr;50(4):1021-1025.

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