SU-11752 | DNA-PK inhibitor | Probechem Biochemicals

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Chemical Structure : SU-11752

SU-11752 (SU11752)

Catalog No.: PC-61970Not For Human Use, Lab Use Only.

SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells.

Physicochemical Properties

M.Wt	493.57
Formula	C26H27N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[1,2-Dihydro-2-oxo-5-[(phenylamino)sulfonyl]-3H-indol-3-ylidene]methyl]-2,4-diethyl-1H-pyrrole-3-propanoic acid

References

1. Ismail IH, et al. Oncogene. 2004 Jan 29;23(4):873-82.

2. Harnor SJ, et al. ChemMedChem. 2017 Jun 21;12(12):895-900.

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SU-11752 (SU11752)

Biological Activity

Physicochemical Properties

References

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