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Chemical Structure : SW155246
CAS No.: 420092-79-1
Catalog No.: PC-38486Not For Human Use, Lab Use Only.
SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM).
SW155246 showed a variable degree of cell-growth inhibition against HeLa and A549 with IC50 of 8-20 uM.
SW155246 inhibited global methylation in HeLa cells, reactivated expression of the tumor suppressor gene RASSF1A in A549 cells.
| M.Wt | 378.8 | |
| Formula | C16H11ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide |
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1. Kilgore JA, et al. J Biol Chem. 2013 Jul 5;288(27):19673-84.
2. Medina-Franco JL, et al. Int J Mol Sci. 2014 Feb 21;15(2):3253-61.
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