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Chemical Structure : SW2_152F
Catalog No.: PC-72295Not For Human Use, Lab Use Only.
SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.
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SW2_152F (SW2 152F, SW2-152F is a potent, selective, cell permeable CBX2 chromodomain probe inhibitor, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.
SW2_152F displays 24-1,000-fold selectivity for CBX2 ChD over other CBX paralogs (CBX4/6/7/8) in vitro.
SW2_152F is cell permeable, selectively inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation.
| M.Wt | 935.382 | |
| Formula | C45H62Cl3N7O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sijie Wang, et al. Chembiochem. 2021 Jul 1;22(13):2335-2344.
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