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SW2_152F

Chemical Structure : SW2_152F

CAS No.:

SW2_152F (SW2 152F, SW2-152F)

Catalog No.: PC-72295Not For Human Use, Lab Use Only.

SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SW2_152F (SW2 152F, SW2-152F is a potent, selective, cell permeable CBX2 chromodomain probe inhibitor, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.
    SW2_152F displays 24-1,000-fold selectivity for CBX2 ChD over other CBX paralogs (CBX4/6/7/8) in vitro.
    SW2_152F is cell permeable, selectively inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation.

    Physicochemical Properties

    M.Wt 935.382
    Formula C45H62Cl3N7O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((2S,5S,8S,11S,14S)-8-((S)-sec-butyl)-1-(3-chloro-4-hydroxyphenyl)-5-cyclopentyl-11-(4-(diethylamino)butyl)-14-(hydroxymethyl)-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazanonadec-18-yn-2-yl)-3,5-dichlorobenzamide

    References

    1. Sijie Wang, et al. Chembiochem. 2021 Jul 1;22(13):2335-2344.

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