SW2_152F | CBX2 inhibitor | Probechem Biochemicals

Chemical Structure : SW2_152F

SW2_152F (SW2 152F, SW2-152F)

Catalog No.: PC-72295Not For Human Use, Lab Use Only.

SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.

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Biological Activity

SW2_152F (SW2 152F, SW2-152F is a potent, selective, cell permeable CBX2 chromodomain probe inhibitor, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.
SW2_152F displays 24-1,000-fold selectivity for CBX2 ChD over other CBX paralogs (CBX4/6/7/8) in vitro.
SW2_152F is cell permeable, selectively inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation.

Physicochemical Properties

M.Wt	935.382
Formula	C45H62Cl3N7O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,5S,8S,11S,14S)-8-((S)-sec-butyl)-1-(3-chloro-4-hydroxyphenyl)-5-cyclopentyl-11-(4-(diethylamino)butyl)-14-(hydroxymethyl)-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazanonadec-18-yn-2-yl)-3,5-dichlorobenzamide

References

1. Sijie Wang, et al. Chembiochem. 2021 Jul 1;22(13):2335-2344.

SW2_152F (SW2 152F, SW2-152F)

Biological Activity

Physicochemical Properties

References

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