SW2_152F (SW2 152F, SW2-152F)

Chemical Structure : SW2_152F

CAS No.:

Catalog No.: PC-72295Not For Human Use, Lab Use Only.

SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.

Packing	Price	Stock
2 mg	$298	In stock
5 mg	$498	In stock
10 mg	$758	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe inhibitor, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.
SW2_152F displays 24-1,000-fold selectivity for CBX2 ChD over other CBX paralogs (CBX4/6/7/8) in vitro.
SW2_152F is cell permeable, selectively inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation.

Physicochemical Properties

M.Wt	935.382
Formula	C45H62Cl3N7O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,5S,8S,11S,14S)-8-((S)-sec-butyl)-1-(3-chloro-4-hydroxyphenyl)-5-cyclopentyl-11-(4-(diethylamino)butyl)-14-(hydroxymethyl)-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazanonadec-18-yn-2-yl)-3,5-dichlorobenzamide

References

1. Sijie Wang, et al. Chembiochem. 2021 Jul 1;22(13):2335-2344.