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SWE101

Chemical Structure : SWE101

CAS No.: 2376322-12-0

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SWE101 (SWE-101, SWE 101)

Catalog No.: PC-73058Not For Human Use, Lab Use Only.

SWE101 (SWE-101, SWE 101) is a potent, selective, in vivo active inhibitor of soluble epoxide hydrolase (sEH) phosphatase domain (sEH-P) with IC50 of 58 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SWE101 (SWE-101, SWE 101) is a potent, selective, in vivo active inhibitor of soluble epoxide hydrolase (sEH) phosphatase domain (sEH-P) with IC50 of 58 nM.
SWE101 showed no significantactivity against sEH-H activity, did not inhibit either the hydrolase or phosphatase activity of mouse sEH.
SWE101 is active in rats with favorable pharmacokinetics and revealed the involvement of sEH-P in LPA hydrolysis.

Physicochemical Properties

M.Wt 376.233
Formula C19H15Cl2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-(3,4-Dichlorophenyl)-5-phenyloxazol-2-yl)butanoic acid

References

1. Kramer JS, et al. J Med Chem. 2019 Sep 26;62(18):8443-8460.

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