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SX-682

Chemical Structure : SX-682

CAS No.: 1648843-04-2

SX-682 (SX682)

Catalog No.: PC-73125Not For Human Use, Lab Use Only.

SX-682 (SX682) is a potent, allosteric, orally bioavailable inhibitor of CXCR1 and CXCR2.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SX-682 (SX682) is a potent, allosteric, orally bioavailable inhibitor of CXCR1 and CXCR2.
SX-682 enhances tumor infiltration, activation, and the therapeutic efficacy of adoptively transferred NK cells.
SX-682 significantly inhibits trafficking of PMN-MDSCs without altering CXCR2 ligand expression.
SX-682 enhances T cell-based immunotherapeutic efficacy.

Physicochemical Properties

M.Wt 467.202
Formula C19H14BF4N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(((5-((4-Fluorophenyl)carbamoyl)pyrimidin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid

References

1. Lu X, et al. Nature. 2017 Mar 30;543(7647):728-732.

2. Sun L, et al. JCI Insight. 2019 Apr 4;4(7). pii: 126853. doi: 10.1172/jci.insight.126853.

3. Greene S, et al. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.

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