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Saikosaponin D

Chemical Structure : Saikosaponin D

CAS No.: 20874-52-6

Saikosaponin D

Catalog No.: PC-27755Not For Human Use, Lab Use Only.

Saikosaponin D is an active component isolated from Bupleurum falcatum, inhibits activated T lymphocyte proliferation by downregulating the NF-κB, NF-AT, and AP-1 signaling pathways, suppresses enterovirus A71 infection (EV-A71) by inhibiting autophagy, also potently inhibits the proliferation and invasion of cancer cells, induces the apoptosis of cancer cells, and suppresses angiogenesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Saikosaponin D is an active component isolated from Bupleurum falcatum, inhibits activated T lymphocyte proliferation by downregulating the NF-κB, NF-AT, and AP-1 signaling pathways, suppresses enterovirus A71 infection (EV-A71) by inhibiting autophagy, also potently inhibits the proliferation and invasion of cancer cells, induces the apoptosis of cancer cells, and suppresses angiogenesis.

Physicochemical Properties

M.Wt 780.98
Formula C42H68O13
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

References

1. Li C, et al. Signal Transduct Target Ther. 2019 Feb 22;4:4.

2. Wong VK, et al. J. Cell. Biochem. 2009;107:303–315.

3. Wong VK, et al. Evid.-Based Complement. Altern. Med. 2013;2013:745295.

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