Catalog No.: PC-43497Not For Human Use, Lab Use Only.
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
Sapanisertib (INK-128, MLN0128) inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2.
Sapanisertib (INK-128, MLN0128) also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.
Sapanisertib (INK-128, MLN0128) shows tumor growth inhibition efficacy in multiplexenograft models.
