Saxagliptin (BMS-477118) | DPP4 inhibitor

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Chemical Structure : Saxagliptin

CAS No.: 361442-04-8

Saxagliptin (BMS-477118;BMS 477118;BMS477118)

Catalog No.: PC-42509Not For Human Use, Lab Use Only.

Saxagliptin (BMS-477118) is a highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM.

Packing	Price	Stock
25 mg	$78	In stock
50 mg	$118	In stock
100 mg	$198	In stock
250 mg		Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Saxagliptin (BMS-477118) is a highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM.
Saxagliptin (BMS-477118) shows no CYP3A4 inhibition up to 100 uM, and good oral exposure.

Physicochemical Properties

M.Wt	315.41
Formula	C18H25N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-

References

1. Augeri DJ, et al. J Med Chem. 2005 Jul 28;48(15):5025-37.

2. Kim YB, et al. Arch Biochem Biophys. 2006 Jan 1;445(1):9-18.

3. Ikeda J, et al. J Pharmacol Sci. 2016 Sep;132(1):65-70.

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Saxagliptin (BMS-477118;BMS 477118;BMS477118)

Biological Activity

Physicochemical Properties

References

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