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Saxagliptin hydrate

Chemical Structure : Saxagliptin hydrate

CAS No.: 945667-22-1

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Saxagliptin hydrate (BMS-477118 hydrate, BMS477118 hydrate)

Catalog No.: PC-42510Not For Human Use, Lab Use Only.

Saxagliptin (BMS-477118) hydrate is a highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM.

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25 mg $78 In stock
50 mg $118 In stock
100 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Saxagliptin (BMS-477118) hydrate is a highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM.
Saxagliptin shows no CYP3A4 inhibition up to 100 uM, and good oral exposure.

Physicochemical Properties

M.Wt 333.4253
Formula C18H27N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, hydrate (1:1), (1S,3S,5S)-

References

1. Augeri DJ, et al. J Med Chem. 2005 Jul 28;48(15):5025-37.

2. Kim YB, et al. Arch Biochem Biophys. 2006 Jan 1;445(1):9-18.

3. Ikeda J, et al. J Pharmacol Sci. 2016 Sep;132(1):65-70.

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