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Seclidemstat

Chemical Structure : Seclidemstat

CAS No.: 1423715-37-0

Seclidemstat (SP-2577;SP2577)

Catalog No.: PC-61398Not For Human Use, Lab Use Only.

Seclidemstat (SP-2577, SP2577) is a potent, selecftive and reversible LSD1 inhibitor with IC50 of 13 nM in biochemical assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Seclidemstat (SP-2577, SP2577) is a potent, selecftive and reversible LSD1 inhibitor with IC50 of 13 nM in biochemical assays.
SP-2577 inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 of 0.529 uM for COV434 (SMARCA4).
SP-2577 promotes ERV expression, activates the dsRNA-induced IFN pathway, and enhances T-cell infiltration in SCCOHT.
SP-2577 also promotes PD-L1 expression, and thus can potentially overcome resistance to anti-PD-1 therapy in SCCOHT.

Physicochemical Properties

M.Wt 450.938
Formula C20H23ClN4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N'-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]-3-(4-methylpiperazine-1-sulfonyl)benzohydrazide

References

1. Patent WO/2017/004519 A1.
2. Soldi R, et al. PLoS One. 2020 Jul 10;15(7):e0235705.

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