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Seladelpar

Chemical Structure : Seladelpar

CAS No.: 851528-79-5

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Seladelpar (MBX8025, RWJ800025)

Catalog No.: PC-61150Not For Human Use, Lab Use Only.

Seladelpar (MBX-8025, RWJ800025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist with EC50 of 2 nM, displays >750-fold selective over PPAR-α.

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10 mg $58 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Seladelpar (MBX-8025, RWJ800025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist  with EC50 of 2 nM, displays >750-fold selective over PPAR-α.
Seladelpar (MBX-8025) exhibits anti-cholestatic effects and potential for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).

Physicochemical Properties

M.Wt 444.465
Formula C21H23F3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid

References

1. Bays HE, et al. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97.

2. Jones D, et al. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):716-726.

3. Choi YJ, et al. Atherosclerosis. 2012 Feb;220(2):470-6.

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