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Chemical Structure : Seriniquinone
Catalog No.: PC-70326Not For Human Use, Lab Use Only.
Seriniquinone (S 747855) is a melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.
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Seriniquinone (S 747855) is a melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.
Seriniquinone demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines.
Seriniquinone increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells.
Seriniquinone causes an increasing level of DCD expression directly correlated with cell line selectivity,
| M.Wt | 344.34 | |
| Formula | C20H8O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Trzoss L, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92.
2. Matsuoka M, et al. J Heterocycl Chem. 1991;28(5):1445–1447.
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