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Shield-1

Chemical Structure : Shield-1

CAS No.: 914805-33-7

Shield-1 (Shld-1;Shield 1;Shield 1)

Catalog No.: PC-60184Not For Human Use, Lab Use Only.

Shield-1 is a cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Shield-1 is a cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation.
Shield-1 binds tightly to FKBP, induces rapid and processive degradation of the LID domain and any fused partner protein.

Physicochemical Properties

M.Wt 748.9
Formula C42H56N2O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl) propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

References

1. Banaszynski, et al. Cell. 2006 Sep 8; 126(5):995-1004.

2. Rodriguez S, et al. Chem Biol. 2012 Mar 23;19(3):391-8.

3. Bonger KM, et al. Nat Chem Biol. 2011 Jul 3;7(8):531-7.

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