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Siastatin B

Chemical Structure : Siastatin B

CAS No.: 54795-58-3

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Siastatin B

Catalog No.: PC-21646Not For Human Use, Lab Use Only.

Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases.
Siastatin B is a bacterial neuraminidase inhibitor isolated from Streptomyces culture.
Siastatin B also inhibits human cytosolic sialidase (Neuraminidase 2, NEU2).

Physicochemical Properties

M.Wt 218.21
Formula C8H14N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid

References

1. Nishimura Y, et al. J Antibiot (Tokyo). 1993 Dec;46(12):1883-9.

2. Rahman MM, et al. Biochem Biophys Rep. 2015 Sep 25;4:234-242.

3. Chen Y, et al. J Am Chem Soc. 2023 Dec 20. doi: 10.1021/jacs.3c04162.

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