Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Simufilam hydrochloride
CAS No.: 2480226-07-9
Catalog No.: PC-72846Not For Human Use, Lab Use Only.
Simufilam hydrocloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $578 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Simufilam hydrochloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
PTI-125 restores receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
PTI-125 reduces tau hyperphosphorylation, aggregated Aβ42 deposition, neurofibrillary tangles, and neuroinflammation in triple-transgenic (3xTg) Alzheimer's disease (AD) mice.
PTI-125 alleviates neuronal abnormalities and reduced seizure frequency in mice modeling TSC and FCDII with mutations in PI3K-ras homolog enriched in brain (Rheb) pathway genes.
| M.Wt | 295.811 | |
| Formula | C15H22ClN3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one hydrochloride |
|
1. Zhang L, et al. Sci Transl Med. 2020 Feb 19;12(531):eaay0289.
2. Wang HY, et al. Neurobiol Aging. 2017 Jul;55:99-114.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
