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Simufilam hydrochloride

Chemical Structure : Simufilam hydrochloride

CAS No.: 2480226-07-9

Simufilam hydrochloride (PTI-125 hydrochloride, PTI125 hydrochloride)

Catalog No.: PC-72846Not For Human Use, Lab Use Only.

Simufilam hydrocloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Simufilam hydrochloride (PTI-125) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
PTI-125 restores receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
PTI-125 reduces tau hyperphosphorylation, aggregated Aβ42 deposition, neurofibrillary tangles, and neuroinflammation in triple-transgenic (3xTg) Alzheimer's disease (AD) mice.
PTI-125 alleviates neuronal abnormalities and reduced seizure frequency in mice modeling TSC and FCDII with mutations in PI3K-ras homolog enriched in brain (Rheb) pathway genes.

Physicochemical Properties

M.Wt 295.811
Formula C15H22ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one hydrochloride

References

1. Zhang L, et al. Sci Transl Med. 2020 Feb 19;12(531):eaay0289.

2. Wang HY, et al. Neurobiol Aging. 2017 Jul;55:99-114.

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