Sinbaglustat | GCS/GBA2 inhibitor | Probechem Biochemicals

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Chemical Structure : Sinbaglustat

CAS No.: 441061-33-2

Sinbaglustat (ACT-519276, OGT2378)

Catalog No.: PC-26890Not For Human Use, Lab Use Only.

Sinbaglustat (OGT2378) is an orally available, blood-brain barrier permeable dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2), Sinbaglustat is 50‐fold more potent in inhibiting GBA2 than GCS.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	233.31
Formula	C11H23NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-pentylpiperidine-3,4,5-triol

References

1. Melchior M, et al. J Clin Pharmacol. 2021 Jul;61(7):932-938.

2. Aravind A, et al. J Org Chem. 2009 Apr 3;74(7):2858-61.

3. Weiss M, et al. Cancer Res. 2003 Jul 1;63(13):3654-8.

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Sinbaglustat (ACT-519276, OGT2378)

Biological Activity

Physicochemical Properties

References

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