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Chemical Structure : Sirpiglenastat
CAS No.: 2079939-05-0
Catalog No.: PC-38422Not For Human Use, Lab Use Only.
DRP-104 (Sirpiglenastat) is a novel broad acting glutamine antagonist, has significant anticancer activity by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $378 | In stock | |
| 10 mg | $578 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DRP-104 (Sirpiglenastat) is a novel broad acting glutamine antagonist, has significant anticancer activity by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.
DRP-104 (Sirpiglenastat) has significant single agent activity in various tumor types, including KEAP1 and STK11 mutant non-small cell lung cancers (NSCLC), osimertinib resistant NSCLC as well as PIK3CA/PTEN mutant head and neck squamous cell carcinoma (SCCHN).
DRP-104 mediated tumor growth inhibition (TGI) is associated with increased tumor-infiltrating leukocytes (TIL) including T, NKT, and NK cells; M1-polarized tumor associated macrophages; and decreased immune-suppressive cells such as MDSCs.
| M.Wt | 441.488 | |
| Formula | C22H27N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
isopropyl (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate |
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1. Yumi Yokoyama, et al. Cancer Res (2021) 81 (13_Supplement): 1563.
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